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Growth Hormone
Vial: 5 mg

How is CJC-1295 DAC (5 mg) + Ipamorelin (5 mg) Stack dosed and mixed?

CJC-1295 DAC (5 mg) + Ipamorelin (5 mg) Stack is a peptide stack research reference in the Growth Hormone category for a 5 mg vial. The reference mixing guide adds 2 mL of bacteriostatic water, giving a concentration of 2.5 mg/mL. The published research schedule lists 1–2 mg per week, once weekly for 8–12 weeks minimum; it is reference information, not a recommendation.

By Vincent Ceniceros · Published · Last updated

This stacked protocol combines CJC-1295 DAC, a long-acting GHRH analog with extended half-life via albumin binding, and Ipamorelin, a selective ghrelin-receptor agonist that triggers potent GH pulses with minimal ACTH/cortisol release. Together, these peptides amplify endogenous growth hormone secretion and IGF-1 signaling through complementary mechanisms.

Dose
1–2 mg per week
Frequency
Once weekly
Timing
Before bed
Duration
8–12 weeks minimum

Long-acting GH secretagogue. Provides sustained GH elevation. Often combined with Ipamorelin.

Dosing Schedule
PhaseWeekly Dose (mcg / mg)Units (mL) per InjectionFrequency
Standard1000 mcg (1.0 mg)40 units (0.40 mL)Once weekly
Aggressive2000 mcg (2.0 mg)80 units (0.80 mL)Once weekly
Mixing & Quick Reference
Bacteriostatic water
2 mL
Concentration
2.5 mg/mL
  • •CJC-1295 DAC: Add 2.0 mL bacteriostatic water → 2.5 mg/mL; inject once weekly.
  • •Ipamorelin: Add 3.0 mL bacteriostatic water → 1.67 mg/mL; inject once daily.
  • •Easy measuring: CJC-1295 DAC: 1 unit = 25 mcg; Ipamorelin: 1 unit ≈ 16.7 mcg on U-100 syringes.
  • •Storage: Lyophilized: ≤ −15 °C (5 °F); reconstituted: 2–8 °C (35.6–46.4 °F); use within 3–4 weeks.
Supplies Needed
  • •CJC-1295 DAC Vials (5 mg each):
  • •Ipamorelin Vials (5 mg each):
  • •Insulin Syringes (U-100):
  • •For Ipamorelin doses ≤10 units, 30- or 50-unit syringes improve accuracy.
  • •Bacteriostatic Water (10 mL bottles):
  • •Alcohol Swabs:
Benefits
  • •Body composition: GH secretagogues have demonstrated improvements in lean mass and reductions in fat mass in clinical studies.
  • •Sustained GH/IGF-1 elevation: CJC-1295 DAC produces prolonged elevations lasting 6–11 days per administration.
  • •Selectivity: Ipamorelin does not significantly increase cortisol or ACTH at therapeutic doses.
  • •Tolerability: Both peptides were well tolerated in human studies, with transient injection-site reactions being the most common adverse effect.
  • •Water retention, mild headache, and transient numbness/tingling have been reported with GH-elevating compounds.
How It Works

CJC-1295 DAC functions as a synthetic GHRH analog that stimulates pituitary GH release. Its Drug Affinity Complex (DAC) moiety binds to serum albumin, extending its half-life to approximately 6–8 days and producing sustained, dose-dependent elevations in GH and IGF-1. Ipamorelin is a selective growth hormone secretagogue that activates the ghrelin receptor (GHSR) to trigger rapid GH pulses without significantly affecting ACTH, cortisol, or prolactin. When combined, these peptides act through complementary pathways—GHRH receptor and ghrelin receptor—to synergistically amplify endogenous GH secretion.

References and original studies

  • Journal of Clinical Endocrinology & Metabolism

    Prolonged stimulation of GH and IGF-I secretion by CJC-1295 in healthy adults

    View original study

  • European Journal of Endocrinology

    Ipamorelin, the first selective growth hormone secretagogue

    View original study

  • Endocrine Reviews

    Growth hormone secretagogues: mechanisms and clinical applications

    View original study

  • Sleep Medicine Reviews

    Sleep and the GH/IGF-1 axis: physiological and clinical implications

    View original study

  • Bachem

    Handling and storage guidelines for peptides (lyophilized stability)

    View source

  • Bachem

    Reconstituted peptide storage and stability recommendations

    View source

  • Translational Andrology and Urology (PMC)

    GH secretagogues in body composition management for hypogonadal males

    View original study

  • International Journal of Surgery (PubMed)

    Ipamorelin for postoperative ileus: tolerability and safety in bowel resection patients

    View original study

  • NCBI Bookshelf

    Parenteral medication administration: subcutaneous injection technique

    View original study

  • CDC

    Vaccine administration guidelines: subcutaneous route (no aspiration required)

    View source

  • Growth Hormone & IGF Research (ScienceDirect)

    Ipamorelin induces longitudinal bone growth in rats

    View source

  • Physiological Reviews

    The somatotropic axis: GH and IGF-1 regulation and actions

    View original study

  • Clinical Drug Investigation (PMC)

    Subcutaneous drug delivery: pharmacokinetic considerations

    View original study

About the author

Vincent Ceniceros

Vincent Ceniceros created Peptide Companion and publishes its Dosage Library. Each guide summarizes a reference protocol and links to the studies and sources it draws on.

Published · Last updated

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Work out the mixing math for any vial with the peptide reconstitution calculator, or browse the full Dosage Library.

Educational content adapted from peptidedosages.com. Not medical advice.