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Peptide Companion
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Weight Management
Vial: 50 mg

5-Amino-1MQ (50 mg Vial)

5-Amino-1MQ dosage protocols center on this selective, cell-permeable NNMT (Nicotinamide N-methyltransferase) inhibitor studied for its potential to support fat metabolism, preserve lean muscle mass, and elevate intracellular NAD+ levels. By blocking NNMT, 5-Amino-1MQ may help restore cellular energy balance and activate SIRT1 pathways associated with metabolic efficiency. This educational protocol presents a subcutaneous injection approach to maximize bioavailability from the 50 mg vial format.

Detailed protocol below.

Dosing Schedule
PhaseDaily Dose (mg)Units (per injection) (mL)
Days 1–2 (Tolerance)2.5 mg once daily20 units (0.20 mL)
Days 3+ (Standard)5 mg once daily40 units (0.40 mL)
Alternative BID2.5 mg twice daily20 units (0.20 mL) × 2
Supplies Needed
  • •5-Amino-1MQ Vials (50 mg each): - 1 week (5 mg/day) ≈ 1 vial - 2 weeks (5 mg/day) ≈ 1 vial - 4 weeks (5 mg/day) ≈ 2 vials
  • •Insulin Syringes (U-100): - Per week (once daily): 7 syringes - Per week (BID): 14 syringes - 4 weeks (once daily): 28 syringes
  • •Bacteriostatic Water (10 mL bottles): Use 4.0 mL per vial for reconstitution. - 1 week (1 vial): 4 mL → 1 × 10 mL bottle - 2 weeks (1 vial): 4 mL → 1 × 10 mL bottle - 4 weeks (2 vials): 8 mL → 1 × 10 mL bottle
  • •Alcohol Swabs: One for the vial stopper + one for the injection site each administration. - Per week (once daily): 14 swabs - 4 weeks (once daily): 56 swabs → recommend 1 × 100-count box
References

  • Nature Medicine (2014)

    Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

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  • PMC (2024)

    Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunctions

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  • Frontiers in Pharmacology (2024)

    NNMT: a novel therapeutic target for metabolic syndrome

    View source

  • PubMed (2021)

    LC-MS/MS assay for 5-amino-1-methylquinolinium: pharmacokinetic and oral bioavailability study

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  • ResearchGate (2021)

    Combined NNMT inhibition and reduced-calorie diet normalizes body composition in obese mice

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  • PMC (2022)

    Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice

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  • NMN.com / Scientific Reports

    Role of NNMT inhibition in muscle strength: enhanced grip strength with exercise

    View source

  • Swolverine

    5-Amino-1MQ mechanism, benefits, stacking and cycling guide

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  • PMC

    Subcutaneous drug injection review: pharmacologic considerations

    View source

  • CDC

    Vaccine administration: subcutaneous route (angle/site; no aspiration)

    View source

  • CDC (Subcut Injection PDF)

    Technique diagram and site guidance for subcutaneous injections

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  • NCBI Bookshelf

    Best practices for injection (asepsis, preparation, and administration)

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  • Journal of Medicinal Chemistry (ACS)

    Bisubstrate inhibitors of NNMT with enhanced activity

    View source

  • PMC

    NNMT: a bad actor in fat makes good in liver

    View source

Educational content adapted from peptidedosages.com. Not medical advice.