Peptide Companion
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Peptide Companion
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Weight Management
Vial: 10 mg

Adipotide (10 mg Vial)

Adipotide is a synthetic peptidomimetic that targets prohibitin on blood vessels within white adipose tissue and delivers a pro‑apoptotic sequence to destroy those vessels, resulting in targeted fat mass reduction as fat cells lose their blood supply. Preclinical studies showed notable weight loss in obese rodents and primates; however, clinical development was discontinued after a Phase 1 trial due to safety concerns. This educational protocol presents a cautious once‑daily subcutaneous titration approach with careful dose escalation.

Detailed protocol below.

Dosing Schedule
WeekDaily Dose (mcg)Units (per injection) (mL)
Weeks 1–2250 mcg7.5 units (0.08 mL)
Weeks 3–4500 mcg15 units (0.15 mL)
Weeks 5–6750 mcg22.5 units (0.23 mL)
Weeks 7–81000 mcg (1.0 mg)30 units (0.30 mL)
Supplies Needed
  • •Peptide Vials (Adipotide, 10 mg each):
  • •Insulin Syringes (U‑100):
  • •Bacteriostatic Water (10 mL bottles): Use ~3.0 mL per vial for reconstitution.
  • •Alcohol Swabs: One for the vial stopper + one for the injection site each day.
References

  • Science Translational Medicine (PubMed)

    A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys

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  • MD Anderson Cancer Center

    Obese Monkeys Lose Weight on Drug that Attacks Blood Supply of Fat Cells

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  • Arrowhead Pharmaceuticals News

    Dosing of First Patient with Anti-Obesity Treatment Adipotide in a Phase 1 Clinical Trial

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  • Cardiovascular Diabetology (PMC)

    Advances and challenges of targeting epicardial adipose tissue (EAT) and perivascular adipose tissue (PVAT)

    View source

  • Bachem Technical Note

    Care and Handling of Peptides

    View source

  • BC Open Textbook Project

    7.3 Intradermal and Subcutaneous Injections – Clinical Procedures for Safer Patient Care

    View source

  • Immunize.org (IAC)

    Ask the Experts: Administering Vaccines – General Issues (no aspiration guidance)

    View source

  • Los Angeles Times

    Cancer treatment shows promise for rapid weight loss

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  • ScienceDaily

    Obese monkeys lose weight on drug that attacks blood supply of fat cells

    View source

  • CDC

    Vaccine administration: subcutaneous route guidance

    View source

  • CDC (Subcut Injection PDF)

    Technique diagram and site guidance for subcutaneous injections

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  • NCBI Bookshelf

    Best practices for injection (asepsis, preparation, and administration)

    View source

  • Subcutaneous Drug Injection Review (PMC)

    Pharmacologic considerations of the subcutaneous route

    View source

Educational content adapted from peptidedosages.com. Not medical advice.