Peptide Companion
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Peptide Companion
single
Anti-Aging
Vial: 10 mg

FOXO4-DRI (10 mg Vial)

FOXO4-DRI (also known as Proxofim) is a synthetic D-retro-inverso peptide designed to selectively induce apoptosis in senescent cells by disrupting the FOXO4–p53 protein interaction. When this interaction is blocked, p53 translocates to the mitochondria in senescent cells, triggering their programmed death while sparing healthy cells. This educational protocol presents a once-daily subcutaneous approach using a practical dilution for precise insulin-syringe measurements.

Detailed protocol below.

Dosing Schedule
WeekDaily Dose (mcg)Units (per injection) (mL)
Weeks 1–4250 mcg7.5 units (0.075 mL)
Weeks 5–8375 mcg11 units (0.11 mL)
Weeks 9–12500 mcg15 units (0.15 mL)
Weeks 13–16500 mcg15 units (0.15 mL)
Supplies Needed
  • •Peptide Vials (FOXO4-DRI, 10 mg each):
  • •Insulin Syringes (U-100):
  • •Bacteriostatic Water (10 mL bottles): Use ~3.0 mL per vial for reconstitution.
  • •Alcohol Swabs: One for the vial stopper + one for the injection site each day.
References

  • Nature Communications Biology

    FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation

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  • Aging (Albany NY)

    FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice

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  • Journal of Cellular and Molecular Medicine

    FOXO4 peptide targets myofibroblast ameliorates bleomycin-induced pulmonary fibrosis in mice

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  • Cell

    Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice (senolytic mechanism context)

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  • Aging (Albany NY) — Methods & Protocols

    Methods & Protocols**

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  • PubMed

    A liquid chromatography high-resolution mass spectrometry in vitro assay to assess metabolism at the injection site of subcutaneously administered therapeutic peptides

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  • Bachem

    Care and Handling of Peptides (storage, reconstitution, stability guidance)

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  • MedlinePlus

    Subcutaneous (SQ) injections: technique, site selection, and safety

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  • American Diabetes Association

    Insulin injection site rotation and lipohypertrophy prevention

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  • CDC

    Vaccine administration: subcutaneous route (angle, site; no aspiration)

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  • CDC (Subcutaneous Injection PDF)

    Technique diagram and site guidance for subcutaneous injections

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  • NCBI Bookshelf

    Best practices for injection (asepsis, preparation, and administration)

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  • PMC

    Subcutaneous Drug Injection Review: pharmacologic considerations of the subcutaneous route

    View source

Educational content adapted from peptidedosages.com. Not medical advice.