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Vial: 50 mg

AICAR (50 mg Vial)

AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) is a research compound that activates AMP-activated protein kinase (AMPK), earning the nickname “exercise pill” after studies showed sedentary animals given AICAR experienced dramatic endurance improvements. AICAR is prohibited in sports (WADA classifies it as a metabolic modulator) and is not approved for therapeutic use in humans. This educational protocol presents a once-daily subcutaneous approach for research purposes only.

Dose
50–150 mg per injection
Frequency
2–3 times weekly
Timing
Pre-workout
Duration
8–12 weeks

AMPK activator. Exercise mimetic. Improves endurance and fat oxidation. High doses may be needed.

Dosing Schedule
Week/PhaseDaily DoseUnits (per injection) (mL)
Weeks 1–21,000 mcg (1 mg)6 units (0.06 mL)
Weeks 3–42,000 mcg (2 mg)12 units (0.12 mL)
Weeks 5–83,000 mcg (3 mg)18 units (0.18 mL)
Supplies Needed
  • •Peptide Vials (AICAR, 50 mg each):
  • •Insulin Syringes (U-100, or 30/50-unit for precision):
  • •Bacteriostatic Water (10 mL bottles): Use 3.0 mL per vial for reconstitution.
  • •Alcohol Swabs: One for the vial stopper + one for the injection site each day.
References

  • U.S. Anti-Doping Agency (USADA)

    What Athletes Should Know About AICAR and Other Prohibited AMPK Activated Protein Kinase Activators (official guidance, 2022)

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  • PubMed

    Doping control study of AICAR; endurance enhancement in sedentary animals (Drug Testing and Analysis, 2017)

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  • PMC (PubMed Central)

    AICAR treatment for 14 days normalizes obesity-induced dysregulation in skeletal muscle (Am. J. Physiol., 2010)

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  • MDPI (International Journal of Molecular Sciences)

    AICAR prevents and reverses diabetic polyneuropathy by regulating mitophagy (2024)

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  • PubMed

    Acadesine (AICAR) Phase I/II study; maximum tolerated dose 210 mg/kg IV (Cancer Chemotherapy and Pharmacology, 2013)

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  • Cell Signaling Technology

    AICAR (Acadesine) Product Data Sheet; AMPK activation mechanism and cellular effects (2021)

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  • JAMA Network

    Effect of adenosine-regulating agent acadesine in cardiac surgery; IV infusion protocol (JAMA, 1997)

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  • Endocrinology (Oxford University Press)

    AICAR stimulates fatty acid oxidation via β-adrenergic pathway in skeletal muscle

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  • PMC

    AICAR enhances glucose transport and mitochondrial function in muscle cells

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  • NCBI Bookshelf

    Best practices for injection procedures; asepsis, preparation, and administration guidelines

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  • MedlinePlus Medical Encyclopedia

    Subcutaneous (SQ) injections: patient instructions for proper technique and site rotation (NIH, 2023)

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  • CDC

    Vaccine administration: subcutaneous route guidelines (angle, site selection, no aspiration)

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  • PMC

    Pharmacologic considerations of subcutaneous drug injection; bioavailability and technique review

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  • Biolog Life Science Institute

    Technical Information about AICAR-5′-MP (AICA Ribonucleotide); stability and handling (2018)

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Educational content adapted from peptidedosages.com. Not medical advice.