Peptide Companion
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Peptide Companion
single
Sleep
Vial: 5 mg

DSIP (5 mg Vial)

Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide (9 amino acids) first isolated from rabbit brain tissue and studied for its effects on sleep architecture and stress modulation. Research indicates DSIP may promote delta-wave (slow-wave) sleep, modulate cortisol and ACTH levels, and exhibit stress-protective properties. This educational protocol presents a once-daily subcutaneous approach using a practical dilution for clear insulin-syringe measurements.

Detailed protocol below.

Dosing Schedule
WeekDaily Dose (mcg)Units (per injection) (mL)
Week 1100 mcg6 units (0.06 mL)
Week 2150 mcg9 units (0.09 mL)
Week 3200 mcg12 units (0.12 mL)
Weeks 4–8250–300 mcg15–18 units (0.15–0.18 mL)
Supplies Needed
  • •Peptide Vials (DSIP, 5 mg each):
  • •Insulin Syringes (U-100):
  • •Bacteriostatic Water (10 mL bottles): Use ~3.0 mL per vial for reconstitution.
  • •Alcohol Swabs: One for the vial stopper + one for the injection site each day.
References

  • Schoenenberger GA, Monnier M (1977)

    Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proc Natl Acad Sci USA

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  • European Journal of Anaesthesiology (2001)

    Delta sleep-inducing peptide: editorial review of mechanisms and clinical context

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  • Schneider-Helmert D, Schoenenberger GA (1983)

    Effects of DSIP in man: multifunctional psychophysiological properties. Neuropsychobiology

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  • Sudakov KV et al. (2004)

    Delta-sleep-inducing peptide sequelae: stress protective effect. Ann N Y Acad Sci

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  • Schneider-Helmert D (1981)

    Acute and delayed effects of DSIP on human sleep behavior. Int J Clin Pharmacol Ther Toxicol

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  • Graf MV, Kastin AJ (1984)

    Delta-sleep-inducing peptide (DSIP): a review. Neurosci Biobehav Rev

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  • Iyer KS et al. (1988)

    Sleep-inducing effect of low doses of DSIP in rats. Indian J Exp Biol

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  • Manning MC et al. (2010)

    Stability of protein pharmaceuticals: an update. Pharm Res

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  • Wang W (2000)

    Lyophilization and development of solid protein pharmaceuticals. Int J Pharm

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  • Yehuda S, Carasso RL (1988)

    DSIP: brain mechanisms and function. Int J Neurosci

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  • Khvatova EM et al. (2003)

    Delta sleep-inducing peptide: effect on oxidative stress in brain during different models. Biull Eksp Biol Med

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  • CDC

    Vaccine administration: subcutaneous route (angle/site; no aspiration)

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  • NCBI Bookshelf

    Medication Administration: Subcutaneous Injections (Open RN Nursing Skills)

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Educational content adapted from peptidedosages.com. Not medical advice.