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Sexual Health
Vial: 5000 IU

HCG (5000 IU Vial)

Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone that mimics luteinizing hormone (LH) by binding to LH receptors in the gonads. With a 36‑hour half‑life (compared to LH’s 30 minutes), HCG provides sustained stimulation of testosterone production in men and ovulation induction in women. This educational protocol presents a practical three‑times‑weekly subcutaneous approach for maintaining testicular function and fertility.

Dose
250–500 IU per injection
Frequency
2–3 times weekly
Timing
Any time of day
Duration
Protocol dependent

LH mimetic. Maintains testicular function during TRT. Fertility preservation research.

Dosing Schedule
Week/PhaseDose per Injection (IU)Units (per injection) (mL)
Weeks 1–12500 IU20 units (0.20 mL)
Supplies Needed
  • •Peptide Vials (HCG, 5000 IU each):
  • •Insulin Syringes (U‑100):
  • •Bacteriostatic Water (10 mL bottles): Use 2.0 mL per vial for reconstitution.
  • •Alcohol Swabs: One for the vial stopper + one for the injection site each injection day.
References

  • National Center for Biotechnology Information (NCBI)

    Human Chorionic Gonadotropin: structure, function, and LH receptor binding mechanisms

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  • Seminars in Reproductive Medicine

    Pharmacokinetics and pharmacodynamics of HCG: extended half‑life and sustained activity

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  • Translational Andrology and Urology (2018)

    Lee JA & Ramasamy R: Review of hCG for hypogonadal male infertility (typical regimens: 1,500–5,000 IU 2–3×/week)

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  • The Journal of Clinical Endocrinology & Metabolism (2005)

    Coviello AD et al: Low‑dose hCG maintains intratesticular testosterone in men with testosterone‑induced gonadotropin suppression

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  • Male Infertility Guide

    Clinical commentary on hCG dosing: 500 IU SC 3×/week for maintenance; 1,000–4,000 IU 3×/week for post‑androgen recovery

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  • Drugs.com (2025)

    HCG Dosage Guide: Adult dose for male hypogonadism: 500–1,000 IU IM 3×/week for 3 weeks, then 2×/week; or 4,000 IU 3×/week for 6–9 months

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  • Mayo Clinic

    Chorionic Gonadotropin drug description: uses for ovulation induction, sperm production, and cryptorchidism treatment

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  • University Hospitals Fertility Center

    Patient instructions for low‑dose HCG: storage at room temperature (unreconstituted); refrigeration after mixing

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  • FDA Prescribing Information

    Chorionic Gonadotropin (Pregnyl/Novarel): reconstituted solution stable for 60 days when refrigerated; do not freeze

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  • University Hospitals Fertility Center

    SC injection technique for HCG: clean site, pinch skin, insert straight in, inject slowly, wait before removing needle; never reuse syringes

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  • Healthline (2019)

    How to Inject hCG: step‑by‑step SC and IM injection instructions for fertility and hormone therapy applications

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  • NCBI Bookshelf

    Best practices for medication injection: aseptic technique, preparation, and safe administration procedures

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  • British Journal of Clinical Pharmacology (1995)

    Lijesen GK et al: Meta‑analysis concluding no scientific evidence supports HCG for weight loss (obesity diet context)

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Educational content adapted from peptidedosages.com. Not medical advice.