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Peptide Companion
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Sexual Health
Vial: 10 mg

Kisspeptin (10 mg Vial)

Kisspeptin (also known as metastin) is a naturally occurring neuroendocrine peptide that plays a pivotal role in human reproduction by stimulating gonadotropin-releasing hormone (GnRH) secretion. This small peptide binds to the GPR54 receptor in the hypothalamus, triggering pulsatile GnRH release and downstream secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Originally identified as a metastasis-suppressor gene product, kisspeptin has become a major focus in reproductive endocrinology. This educational protocol presents a once-daily subcutaneous approach for research use.

Dose
0.001–0.01 mg per injection
Frequency
Research protocol specific
Timing
As per study design
Duration
Study specific

Upstream GnRH regulator. Reproductive endocrinology research. Dosing highly variable.

Dosing Schedule
WeekDaily Dose (mcg)Units (per injection) (mL)
Weeks 1–2100 mcg3 units (0.03 mL)
Weeks 3–8 (or 3–12)200 mcg6 units (0.06 mL)
Supplies Needed
  • •Peptide Vials (Kisspeptin, 10 mg each):
  • •Insulin Syringes (U‑100):
  • •Bacteriostatic Water (10 mL bottles): Use ~3.0 mL per vial for reconstitution.
  • •Alcohol Swabs: One for the vial stopper + one for the injection site each day.
References

  • Endocrine Reviews (Oxford Academic)

    Emerging Therapeutic Potential of Kisspeptin and Neurokinin B

    View source

  • Endocrine Reviews (Oxford Academic)

    Kisspeptin stimulation of GnRH and downstream LH/FSH secretion

    View source

  • Endocrine Reviews (Oxford Academic)

    KiSS-1 gene discovery and role in metastasis suppression

    View source

  • Kisspeptin-10 Clinical Reference Sheet

    Starting dose recommendations and titration guidance

    View source

  • Endocrine Reviews (Oxford Academic)

    Dose-response relationships and titration protocols

    View source

  • Endocrine Reviews (Oxford Academic)

    Tachyphylaxis considerations with prolonged kisspeptin exposure

    View source

  • Endocrine Reviews (Oxford Academic)

    Kisspeptin mechanism: GPR54 receptor binding and GnRH release

    View source

  • Endocrine Reviews (Oxford Academic)

    HPG axis cascade: GnRH stimulation of pituitary LH/FSH

    View source

  • Endocrine Reviews (Oxford Academic)

    GnRH-dependent action of kisspeptin (antagonist studies)

    View source

  • Endocrine Reviews (Oxford Academic)

    Physiologic advantage of kisspeptin vs. direct GnRH/hCG

    View source

  • Kisspeptin-10 Clinical Reference Sheet

    Endogenous testosterone increases via LH pathway

    View source

  • Endocrine Reviews (Oxford Academic)

    Functional hypothalamic amenorrhea: restoration of GnRH pulsatility

    View source

  • Journal of Clinical Investigation

    Kisspeptin-54 triggers egg maturation in IVF with reduced OHSS risk

    View source

  • Endocrine Reviews (Oxford Academic)

    Ovulation trigger applications and OHSS prevention

    View source

  • Prospec Bio

    Lyophilized peptide storage recommendations

    View source

  • Empower Pharmacy

    Bacteriostatic Water handling and 28-day discard guidelines

    View source

  • Clinical Procedures for Safer Patient Care

    Subcutaneous injection technique: angle and site guidance

    View source

  • CDC Vaccine Administration Guidelines

    Subcutaneous route: no aspiration required

    View source

  • NCBI Bookshelf

    Parenteral medication administration: sterile technique and disposal

    View source

Educational content adapted from peptidedosages.com. Not medical advice.