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Peptide Companion
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Healing & Recovery
Vial: 10 mg

KPV (10 mg Vial)

KPV (Lysine–Proline–Valine) is a C‑terminal tripeptide fragment of α‑melanocyte‑stimulating hormone (α‑MSH) studied for its potent anti‑inflammatory properties without melanotropic side effects. Research demonstrates KPV reduces pro‑inflammatory cytokines in models of inflammatory bowel disease and systemic inflammation. This educational protocol presents a once‑daily subcutaneous approach using a practical dilution for precise insulin‑syringe measurements.

Dose
0.5–1 mg per injection
Frequency
Once or twice daily
Timing
Any time of day
Duration
4–8 weeks

Anti-inflammatory tripeptide. Gut health research. Can be administered orally or subcutaneously.

Dosing Schedule
WeekDaily Dose (mcg)Units (per injection) (mL)
Week 1200 mcg6 units (0.06 mL)
Week 2300 mcg9 units (0.09 mL)
Week 3400 mcg12 units (0.12 mL)
Weeks 4–8500 mcg15 units (0.15 mL)
Supplies Needed
  • •Peptide Vials (KPV, 10 mg each):
  • •Insulin Syringes (U‑100):
  • •Bacteriostatic Water (10 mL bottles): Use ~3.0 mL per vial for reconstitution.
  • •Alcohol Swabs: One for the vial stopper + one for the injection site each day.
References

  • Journal of Pharmaceutical Drug Delivery Research (2022)

    Pawar K. et al.: KPV as an α‑MSH fragment retains potent anti‑inflammatory activity without melanotropic side effects

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  • Gastroenterology (2008)

    Dalmasso G. et al.: PepT1‑mediated tripeptide KPV uptake reduces intestinal inflammation in DSS colitis models

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  • Innerbody Research (2025)

    KPV peptide benefits, safety, and administration routes; subcutaneous injection for systemic therapy

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  • Peptides.org Dosage Guide (2023)

    KPV dosage calculator and protocol: 200–400 mcg subcutaneously once daily for inflammation and wound healing

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  • Bachem (Peptide Handling Guidelines)

    Long‑term peptide stability best achieved in lyophilized form at <−15 °C; avoid extended storage in solution

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  • PeptideSciences (Storage Guidelines)

    Lyophilized peptides stable for short‑term at 4 °C, long‑term at −20 °C; reconstituted solutions refrigerated up to ~30 days

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  • Johns Hopkins Arthritis Center

    Subcutaneous injection technique: site preparation, needle angle (45–90°), and injection site rotation

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  • NCBI Bookshelf (Clinical Procedures)

    Best practices for injection: aseptic technique, site preparation, and administration procedures

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  • CDC Vaccine Administration

    Subcutaneous injection route guidance: needle angle, site selection, and no aspiration for subcut injections

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  • PMC (Subcutaneous Drug Injection Review)

    Pharmacologic and physiologic considerations of the subcutaneous route for drug administration

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Educational content adapted from peptidedosages.com. Not medical advice.