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Peptide Companion
single
Anti-Aging
Vial: 20 mg

Vesugen (Lys-Glu-Asp) (20 mg Vial)

Vesugen (Lys-Glu-Asp, also known as KED) is a tripeptide bioregulator synthesized at the Saint Petersburg Institute of Bioregulation and Gerontology. Research suggests it may support vascular endothelial cell proliferation through epigenetic regulation of Ki-67 gene expression. This educational protocol presents a once-daily subcutaneous approach using a practical dilution for clear insulin-syringe measurements.

Detailed protocol below.

Dosing Schedule
WeekDaily Dose (mcg)Units (per injection) (mL)
Week 1500 mcg (0.5 mg)7.5 units (0.075 mL)
Week 21000 mcg (1.0 mg)15 units (0.15 mL)
Week 31500 mcg (1.5 mg)22.5 units (0.225 mL)
Weeks 4–8+1500–2000 mcg (1.5–2.0 mg)22.5–30 units (0.225–0.30 mL)
Supplies Needed
  • •Peptide Vials (Vesugen, 20 mg each):
  • •Insulin Syringes (U-100):
  • •Bacteriostatic Water (10 mL bottles): Use ~3.0 mL per vial for reconstitution.
  • •Alcohol Swabs: One for the vial stopper + one for the injection site each day.
References

  • Bull Exp Biol Med (2016)

    Short Peptides Regulate Gene Expression (Khavinson et al.)

    View source

  • Adv Gerontol (2014)

    Epigenetic aspects of peptidergic regulation of vascular endothelial cell proliferation during aging

    View source

  • Molecules (2021)

    Peptide Regulation of Gene Expression: A Systematic Review (MDPI)

    View source

  • Adv Gerontol (2016)

    Molecular aspects of vasoprotective peptide KED activity during atherosclerosis and restenosis

    View source

  • Bull Exp Biol Med (2021)

    Peptide KED: Molecular-Genetic Aspects of Neurogenesis Regulation in Alzheimer’s Disease

    View source

  • Bull Exp Biol Med (2017)

    Tripeptides Restore the Number of Neuronal Spines under Conditions of In Vitro Modeled Alzheimer’s Disease

    View source

  • Int J Mol Sci (2022)

    Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer’s Disease

    View source

  • Pharmaceuticals (2021)

    Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer’s Disease

    View source

  • DailyMed

    Bacteriostatic Water injection, solution (FDA labeling)

    View source

  • PMC (2024)

    Practical advice in the development of a lyophilized protein drug product

    View source

  • MedlinePlus

    Subcutaneous (SQ) injections: technique and site guidance

    View source

  • NCBI Bookshelf

    Best practices for injection (WHO guidelines)

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  • CDC

    Vaccine administration: subcutaneous injection technique

    View source

  • Biogerontology (2010)

    Peptide bioregulation of aging: Results and prospects (Anisimov & Khavinson)

    View source

  • Stem Cell Rev Rep (2020)

    Peptide Regulation of Cell Differentiation

    View source

Educational content adapted from peptidedosages.com. Not medical advice.