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Sexual Health
Vial: 10 mg

How is PT-141 (10 mg) + Melanotan II (10 mg) Stack dosed and mixed?

PT-141 (10 mg) + Melanotan II (10 mg) Stack is a peptide stack research reference in the Sexual Health category for a 10 mg vial. The reference mixing guide adds 3 mL of bacteriostatic water, giving a concentration of 3.33 mg/mL. The published research schedule lists 0.25–0.5 mg per injection, 3–7 times weekly for Until desired pigmentation achieved; it is reference information, not a recommendation.

By Vincent Ceniceros · Published · Last updated

PT-141 (bremelanotide) and Melanotan II are cyclic melanocortin receptor agonists with distinct but related applications. PT-141 is FDA-approved for hypoactive sexual desire disorder and is used on-demand, while Melanotan II has been studied for its effects on skin pigmentation and sexual function with daily dosing protocols. This educational guide covers reconstitution, dosing, and administration for both peptides.

Dose
0.25–0.5 mg per injection
Frequency
3–7 times weekly
Timing
Any time of day
Duration
Until desired pigmentation achieved

Melanocortin receptor agonist. Promotes tanning. Start low to assess tolerance.

Dosing Schedule
PhaseDose (mcg)Units (per injection) (mL)
Initial / Titration500–750 mcg15–22 units (0.15–0.22 mL)
Standard1000–1500 mcg30–45 units (0.30–0.45 mL)
Full / FDA-Approved1750 mcg (1.75 mg)52 units (0.52 mL)
Mixing & Quick Reference
Bacteriostatic water
3 mL
Concentration
3.33 mg/mL
  • •Reconstitute each: Add 3.0 mL bacteriostatic water → ~ 3.33 mg/mL concentration.
  • •PT-141 dose: 750–1750 mcg on-demand (≥45 min before activity); max 1 dose per 24 h.
  • •Melanotan II dose: 250–1000 mcg once daily with gradual titration.
  • •Easy measuring: At 3.33 mg/mL, 1 unit = 0.01 mL ≈ 33.3 mcg on a U-100 insulin syringe.
  • •Storage: Lyophilized: freeze at −20 °C (−4 °F); reconstituted: refrigerate at 2–8 °C (35.6–46.4 °F) and use within ~1 week.
References and original studies

  • FDA

    Bremelanotide (Vyleesi) prescribing information: dosing, safety, and use limitations

    View source

  • NCBI Bookshelf (LiverTox)

    Bremelanotide: mechanism, clinical use, and hepatic safety profile

    View original study

  • PMC

    Bremelanotide for treatment of female hypoactive sexual desire disorder: clinical trial review

    View original study

  • Mayo Clinic

    Bremelanotide (subcutaneous route): side effects, dosage, and precautions

    View source

  • PubMed

    Evaluation of Melanotan-II: pilot phase-I clinical study on safety and efficacy

    View original study

  • RxList

    Melanotan-II: uses, side effects, dosing, and precautions overview

    View source

  • Bachem

    Handling and storage guidelines for peptides: lyophilized and reconstituted stability

    View source

  • NCBI Bookshelf (WHO)

    Best practices for injections and related procedures: asepsis and technique

    View original study

  • Healthline

    Subcutaneous injection: technique, sites, and step-by-step guidance

    View source

  • CDC

    Vaccine administration: subcutaneous injection angle and site selection

    View source

  • PMC

    Subcutaneous drug injection: pharmacologic considerations and clinical review

    View original study

About the author

Vincent Ceniceros

Vincent Ceniceros created Peptide Companion and publishes its Dosage Library. Each guide summarizes a reference protocol and links to the studies and sources it draws on.

Published · Last updated

Related guides

Work out the mixing math for any vial with the peptide reconstitution calculator, or browse the full Dosage Library.

Educational content adapted from peptidedosages.com. Not medical advice.