Peptide Companion
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Peptide Companion
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Weight Management
Vial: 10 mg

MOTS-C (10 mg Vial)

MOTS-c is a 16–amino-acid mitochondrial-derived peptide (MDP) that acts as a metabolic regulator, primarily through AMPK activation. Preclinical studies show it enhances insulin sensitivity, promotes fat oxidation, improves exercise capacity, and counters age-related metabolic decline. No clinical trials have been completed in humans to date. This educational protocol presents a once-daily subcutaneous approach with gradual titration.

Dose
5–15 mg per injection
Frequency
2–3 times weekly
Timing
Pre-workout preferred
Duration
8–12 weeks

Mitochondrial peptide. Improves insulin sensitivity and metabolic flexibility. Exercise mimetic properties.

Dosing Schedule
WeekDaily Dose (mcg)Units (per injection) (mL)
Weeks 1–2200 mcg (0.2 mg)6 units (0.06 mL)
Weeks 3–4400 mcg (0.4 mg)12 units (0.12 mL)
Weeks 5–6600 mcg (0.6 mg)18 units (0.18 mL)
Weeks 7–8800 mcg (0.8 mg)24 units (0.24 mL)
Weeks 9–10+1,000 mcg (1.0 mg)30 units (0.30 mL)
Supplies Needed
  • •Peptide Vials (MOTS-C, 10 mg each):
  • •Insulin Syringes (U‑100):
  • •Bacteriostatic Water (10 mL bottles): Use ~3.0 mL per vial for reconstitution.
  • •Alcohol Swabs: One for the vial stopper + one for the injection site each day.
References

  • Cell Metabolism (2015)

    The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance (Lee C, Zeng J, Drew BG, et al.)

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  • Journal of Translational Medicine (2023)

    Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging (Wan W, Zhang L, Lin Y, et al.)

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  • Journal of Molecular Medicine (2019)

    MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction (Lu H, Wei M, Zhai Y, et al.)

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  • Nature Communications (2021)

    MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis (Reynolds JC, Lai RW, Woodhead JST, et al.)

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  • Frontiers in Physiology (2023)

    Role of MOTS-c in the regulation of bone metabolism (Yi X, Hu G, Yang Y, et al.)

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  • International Journal of Molecular Sciences (2022)

    MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases (Mohtashami Z, Singh MK, Salimiaghdam N, et al.)

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  • Cognitive Vitality Reports (2021)

    MOTS-c (Cognitive Vitality Profile) – Alzheimer’s Drug Discovery Foundation (ADDF)

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  • USADA Spirit of Sport (2023)

    What is the MOTS-c peptide? – U.S. Anti-Doping Agency education article

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  • CDC Vaccine Administration Guidelines

    Subcutaneous route technique (angle, site selection, no aspiration)

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  • Experimental & Molecular Medicine (2025)

    Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes (Kong BS, Lee H, L’Yi S, et al.)

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  • MedlinePlus Medical Encyclopedia (2023)

    Subcutaneous (SQ) injections – Patient instructions for proper technique

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  • Subcutaneous Drug Injection Review (PMC)

    Literature review of factors influencing subcutaneous injection pharmacology

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Educational content adapted from peptidedosages.com. Not medical advice.