Peptide Companion
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Peptide Companion
single
Weight Management
Vial: 5 mg

MOTS-C (5 mg Vial)

MOTS-C is a 16‑amino-acid mitochondrial‑derived peptide encoded in the mtDNA 12S rRNA region. Discovered in 2015, it enhances metabolic homeostasis through AMPK activation, increases sharply with exercise (~12‑fold in muscle), and declines with age. This educational protocol presents a once‑daily subcutaneous approach aligned with preclinical findings and emerging clinical use.

Dose
5–15 mg per injection
Frequency
2–3 times weekly
Timing
Pre-workout preferred
Duration
8–12 weeks

Mitochondrial peptide. Improves insulin sensitivity and metabolic flexibility. Exercise mimetic properties.

Dosing Schedule
WeekDaily Dose (mcg)Units (per injection) (mL)
Weeks 1–2500 mcg (0.5 mg)30 units (0.30 mL)
Weeks 3–41000 mcg (1.0 mg)60 units (0.60 mL)
Weeks 5–61500 mcg (1.5 mg)90 units (0.90 mL)
Weeks 7–82000 mcg (2.0 mg)120 units (two 60‑unit injections)\*
Supplies Needed
  • •Peptide Vials (MOTS-C, 5 mg each):
  • •Insulin Syringes (U‑100):
  • •Bacteriostatic Water (10 mL bottles): Use ~3.0 mL per vial for reconstitution.
  • •Alcohol Swabs: One for the vial stopper + one for the injection site each day.
References

  • Journal of Translational Medicine (2023)

    Wan W, et al. Mitochondria‑derived peptide MOTS‑c: effects and mechanisms related to stress, metabolism and aging

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  • Cell Metabolism (2015)

    Lee C, et al. The mitochondrial‑derived peptide MOTS‑c promotes metabolic homeostasis and reduces obesity and insulin resistance (PMID: 25738459)

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  • Nature Communications (2021)

    Reynolds JC, et al. MOTS‑c is an exercise‑induced mitochondrial‑encoded regulator of age‑dependent physical decline and muscle homeostasis (DOI: 10.1038/s41467-020-20790-0)

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  • Cell Metabolism (2018)

    Kim KH, et al. The Mitochondrial‑Encoded Peptide MOTS‑c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress (PMID: 29983246)

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  • Rapid Communications in Mass Spectrometry (2019)

    Knoop A, et al. Development of an MS‑based detection method for the mitochondrion‑derived peptide MOTS‑c in plasma for doping control (DOI: 10.1002/rcm.8337)

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  • Alzheimer’s Drug Discovery Foundation (2021)

    Cognitive Vitality Profile: MOTS‑c (evidence review detailing preclinical findings and safety)

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  • CDC

    Vaccine Administration: Administering Vaccines (subcutaneous route guidance; angle, site, no aspiration)

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  • CDC

    Subcutaneous Injection Technique (PDF diagram and site guidance)

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  • NCBI Bookshelf

    Best Practices for Injections: asepsis, preparation, administration, and site rotation

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  • PMC (Pharmacologic Review)

    Pharmacologic considerations of the subcutaneous route for biologics and peptides

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  • Bachem

    Handling and Storage Guidelines for Peptides (manufacturer best‑practices for lyophilized and reconstituted peptides)

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  • Peptide Crafters (2025)

    Stability Study of MOTS‑c Peptide Following Reconstitution and Refrigerated Storage (lab report with purity data over 30 days)

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  • GenScript

    Peptide Storage and Handling Guidelines (freeze‑thaw considerations and best practices)

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  • Sigma‑Aldrich

    Handling and Storage Guidelines for Peptides and Proteins (moisture control, temperature recommendations)

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Educational content adapted from peptidedosages.com. Not medical advice.